Thyroid strain in pregnancy: a nationwide study of iodine nutrition and thyroglobulin among Faroese pregnant women
Authors' conclusion
Thyroglobulin levels increased only in the group of Faroese pregnant women with UIC below 50 µg/L, indicating that strain on the thyroid gland was seen with low UIC levels parallel to that of non-pregnant adults. Our results suggest that the UIC limit recommended in pregnancy may be overly strict and warrant reconsideration to balance health efficacy.
Study context
- Population
- Pregnant women with no known thyroid disease in routine prenatal care, National Hospital System of the Faroe Islands, 2020–2022; 63% of all pregnancies in the periodSerum Thyroglobulin (s-Tg) in subset of 236
- Participants
- 623 women
- Outcome
- Serum Tg and TSH concentration as indicators of thyroid strain and function, by UIC
Methodological detailsnationwide
- Nationwide
Main finding
As reported in the abstract
Serum Tg, TSH and UIC · median gestational week 20
- Elevated TSH
- 0
- Median urinary iodine concentration (UIC)
- 108 µg/L
- Median s-Tg
- 10.3 µg/L
- Serum Tg differed only for UIC below 50 µg/L, not when UIC was above 50 µg/L
- P = .02
- TSH increased with higher UIC
- P < .001
Observational data: associations, not effects.
Original publication
Thyroid strain in pregnancy: a nationwide study of iodine nutrition and thyroglobulin among Faroese pregnant women. Eur J Endocrinol. Published 20 June 2025. doi:10.
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