Thyroid Nodules with Indeterminate Cytological Category in Pediatric Age: Clinical and Surgical Management and Outcome in an Italian Multicentre Retrospective Study
Authors' conclusion
The reported data seem to confirm a greater sensitivity of SIAPEC classification to identify malignancy within the indeterminate category also in pediatric age and not only in adulthood. This finding may orient clinicians toward clinical follow-up for the indeterminate TIR3a group and toward surgical approach with total thyroidectomy in the indeterminate TIR3b group, although this indication should be confirmed in further national multicenter studies including larger cohorts.
Study context
- Population
- Pediatric subjects with thyroid nodules with indeterminate cytological category (SIAPEC), Italy
- Participants
- 44 subjects
- Exposure
- TIR3a vs TIR3b cytological category
- TIR3an = 26
- TIR3bn = 18
- Outcome
- ROM in operated nodules
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
- Total rate of malignancy (ROM)
- 53.8%
Observational data: associations, not effects.
Further findings
| Outcome | TIR3a | TIR3b |
|---|---|---|
| Surgery performed | 8/26 | 18/18 |
Fine-needle aspiration biopsy (FNAB) accuracy for indeterminate cytologic category
- Total FNAB accuracy
- 77%
Original publication
Thyroid Nodules with Indeterminate Cytological Category in Pediatric Age: Clinical and Surgical Management and Outcome in an Italian Multicentre Retrospective Study. Horm Res Paediatr. Published 25 September 2025. doi:10.
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