Threshold of hyperglycaemia associated with mortality in critically ill patients: a multicentre, prospective, observational study using continuous glucose monitoring
Authors' conclusion
A glucose level exceeding 10.5 mmol/l (190 mg/dl) was significantly associated with higher risk of in-hospital mortality in critically ill patients.
Study context
- Population
- Adult critically ill patients admitted to ICUs of five medical centres, May 2020–November 2021
- Participants
- 293 patients
- Outcome
- In-hospital mortality in relation to predefined TARs (thresholds 7.8–13.9 mmol/l [140-250 mg/dl])
Methodological detailsmulticentre, observational, intermittently scanned continuous glucose monitoring (CGM), CGM worn for a median of 12.0 days
- Multicentre
- Observational
- Intermittently scanned CGM
- CGM worn for a median of 12.0 days
Main finding
As reported in the abstract
In-hospital mortality
In-hospital deaths
66
22.5%
Observational data: associations, not effects.
Further findings
TIR 3.9-10.5 mmol/l (70-190 mg/dl), per absolute 10% decrease, and in-hospital mortality
- Risk of in-hospital mortality increased by 12.1% per absolute 10% decrease in TIR 3.9-10.5 mmol/l
- HR 1.121 [95% CI 1.003, 1.253]
- Similar results for time in ranges (TIRs) with various upper thresholds and in-hospital mortality risk
Original publication
Threshold of hyperglycaemia associated with mortality in critically ill patients: a multicentre, prospective, observational study using continuous glucose monitoring. Diabetologia. Published 3 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →