Threshold and Predictive Alerts of Continuous Glucose Monitoring and Glycemic Control in Hospitalized Adults With Diabetes: A Randomized Clinical Trial
Primary result · TIRResult — go to the resultAdjusted mean difference 3.9 % 95% CI 0.1%–7.8%Authors' conclusion
In this randomized clinical trial of hospitalized adults with diabetes, CGM threshold glucose alerts modestly improved glycemic control compared with CGM use without alerts. The addition of predictive alerts did not confer further glycemic benefit beyond threshold alerts alone.
Study context
- Population
- Adults with T1D or T2D admitted to endocrinology wards, tertiary hospital; mean age 62 years, 62.1% male, mean HbA1c 9.2%randomized 1:1:1
- Participants
- 533 adults
- Comparison
- Continuous glucose monitoring (CGM) threshold alerts only vs threshold plus predictive alerts vs all alerts off
- All alerts offn = 178reference
- Threshold alerts onlyn = 177
- Threshold plus predictive alertsn = 178
- Primary endpoint
- Percentage of time within target glucose range 70 to 180 mg/dL (TIR)
- Follow-up
- During hospitalization
Methodological detailssingle-center, open-label, Conducted April 15 to December 9, 2024
- Single-center
- Open-label
- Conducted April 15 to December 9, 2024
Primary result
TIR
Adjusted mean difference
3.9 %
95% CI 0.1%–7.8%
Holm-adjusted P = .04
By group
Threshold alerts onlyvs All alerts off
adjusted mean difference 3.9 % (95% CI 0.1%–7.8%); Holm-adjusted P = .04
As reported in the abstract
Secondary outcomes
| Outcome | Difference (%) (95% CI) | |
|---|---|---|
| Time above range (>180 mg/dL)Threshold alerts onlyvs All alerts off | −3.9 (−7.1% to −0.7%) | |
| Time below range (<70 mg/dL)Threshold alerts onlyvs All alerts offDid not differ between groups | −0.04 (−0.3% to 0.2%) | |
| −10−505Difference, % (linear scale) |
Original publication
Threshold and Predictive Alerts of Continuous Glucose Monitoring and Glycemic Control in Hospitalized Adults With Diabetes: A Randomized Clinical Trial. JAMA Netw Open. Published 3 August 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →