The triglyceride glucose index trajectory is associated with hypertension: a retrospective longitudinal cohort study
Authors' conclusion
Elevated TyG index at baseline and long-term TyG index trajectories were associated with the risk of hypertension. Early identification of increasing TyG index could provide insights for preventing hypertension later in life.
Study context
- Population
- Adults from the Physical Examination Center of the Second Affiliated Hospital of Dalian Medical University, northeast China, 2011–2022; median age 38 years, 48.83% men
- Participants
- 15,056 adults
- Exposure
- TyG index trajectories: moderate increasing and high stable vs low increasing
- Low increasingn = 7,241reference
- Moderate increasingn = 6,448
- High stablen = 1,367
- Outcome
- Incident hypertension
- Follow-up
- 12 years
Methodological detailsgroup-based trajectory modelling, Cox regression
- Group-based trajectory modelling
- Cox regression
Main finding
As reported in the abstract
Hypertension
Each group vs low increasingHazard ratio (95% CI)
Moderate increasing
2.45(2.25–2.67)
High stable
3.88(3.48–4.33)
Moderate increasingadjusted for baseline sex, age, diabetes, smoking, BP, BMI, lipids, glucose, TG, urea, uric acid, GFR
1.38(1.23–1.54)
High stableadjusted for baseline sex, age, diabetes, smoking, BP, BMI, lipids, glucose, TG, urea, uric acid, GFR
1.69(1.40–2.02)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Hypertension, womenModerate increasingvs Low increasing | 2.63 (2.30–3.00) | |
| Hypertension, womenHigh stablevs Low increasing | 4.66 (3.66–5.93) | |
| Hypertension, menModerate increasingvs Low increasing | 1.66 (1.48–1.86) | |
| Hypertension, menHigh stablevs Low increasing | 2.33 (2.04–2.66) | |
| 0.20.5125Hazard ratio (log scale) |
Original publication
The triglyceride glucose index trajectory is associated with hypertension: a retrospective longitudinal cohort study. Cardiovasc Diabetol. Published 15 December 2023. doi:10.
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