The triglyceride-glucose index, a marker of insulin resistance, as a predictor of thrombotic risk in atrial fibrillation
Authors' conclusion
In this real-world cohort of AF patients on OAC, an elevated TyG index independently predicted thrombotic events.
Study context
- Population
- Atrial fibrillation (AF) outpatients starting oral anticoagulation (OAC) between January 2016 and November 2021; 52.5% women; median age 77 years (IQR 69–82)
- Participants
- 2,907 outpatients
- Exposure
- Triglyceride-glucose (TyG) index tertiles
- Outcome
- Composite of thrombotic events:
- MI
- VTE
- Ischemic stroke
- Transient ischemic attack
- Follow-up
- 2 years
Main finding
As reported in the abstract
Composite thrombotic events · 2 years
Estimate (95% CI)P value
T3vs T1
incidence rate ratio 1.39(1.01–1.96)
P = 0.047T3vs T2
incidence rate ratio 1.42(1.01–2.00)
P = 0.038T3vs T164% higher risk of thrombotic events
aHR 1.64(1.17–2.29)
log-rank test p value = 0.014- Composite thrombotic event, all patients
- 7.2% (208)
- TyG index (continuous) as independent predictor, adjusted Cox regression, aHR
- 1.82 (95% CI 1.15-2.89)
- Median TyG index (IQR)
- 4.71 (4.53-4.91)
Observational data: associations, not effects.
Original publication
The triglyceride-glucose index, a marker of insulin resistance, as a predictor of thrombotic risk in atrial fibrillation. Cardiovasc Diabetol. Published 10 July 2025. doi:10.
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