Association between trajectory of triglyceride-glucose index and all-cause mortality in critically ill patients with atrial fibrillation: a retrospective cohort study
Authors' conclusion
In critically ill patients with AF, TyG index trajectories were significantly associated with 30-day, 90-day, 180-day and 365-day all-cause mortality. This suggested that TyG index trajectories could serve as a robust indicator for risk stratification and prognosis assessment in ICU patients with AF.
Study context
- Population
- Critically ill patients diagnosed with atrial fibrillation (AF) in intensive care unit (ICU), MIMIC-IV database
- Participants
- 1,108 patients
- Exposure
- Triglyceride-glucose (TyG) index trajectory groups
- Outcome
- All-cause mortality
- Follow-up
- 30-day, 90-day, 180-day and 365-day follow-up
Methodological detailsgroup-based trajectory modeling, MIMIC-IV database
- Group-based trajectory modeling
- MIMIC-IV database
Main finding
As reported in the abstract
30-day, 90-day, 180-day and 365-day
traj4 vs traj1Hazard ratio (95% CI)
30-day
1.71(1.14–2.56)
90-day
1.67(1.17–2.39)
180-day
1.44(1.03–2.06)
365-day
1.44(1.04–1.98)
Observational data: associations, not effects.
Further findings
TyG index and all-cause mortality (restricted cubic splines (RCS))
- Linear association between TyG index and all-cause mortality
Original publication
Association between trajectory of triglyceride-glucose index and all-cause mortality in critically ill patients with atrial fibrillation: a retrospective cohort study. Cardiovasc Diabetol. Published 10 July 2025. doi:10.
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