The skeletal safety of milk-derived proteins: A meta-analysis of randomized controlled trials
Authors' conclusion
Our findings do not support the claim that proteins of dairy origin are detrimental to bone health.
Study context
- Population
- Adults in randomized controlled trials (RCTs) of milk-derived protein supplementation; PubMed and Web of Science
- Comparison
- Milk-derived protein supplementation vs comparator
- Outcome
- BMD
Methodological detailsrandom-effects model
- Random-effects model
Pooled result
As reported in the abstract
- No significant effect on whole-body BMD (7 RCTs)
- No significant effect on BMD at lumbar spine (10), hip (8), femoral neck (9), trochanter (5), intertrochanter (2), ultradistal radius (2)
- Random-effects model
Further pooled results
Bone turnover markers and PTH
- Bone formation markers (bone-specific alkaline phosphatase [11], osteocalcin [6], P1NP [5]) not significantly affected
- Bone resorption markers (NTX [7], CTX [7], deoxypyridinoline [4]) and PTH (7) not significantly affected
IGF-1
- Increased IGF-1 concentrations (13 RCTs)
- Reduced IGF-1 with soy protein as comparator; increased IGF-1 with carbohydrate as comparator
Original publication
The skeletal safety of milk-derived proteins: A meta-analysis of randomized controlled trials. Osteoporos Int. Published 1 August 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →