The role of renin, fludrocortisone, and hypertension in early childhood in patients with congenital adrenal hyperplasia
Authors' conclusion
Renin suppression in early childhood is associated with increased hypertension risk, whereas higher renin was not associated with growth or electrolyte abnormalities.
Study context
- Population
- Children with 21-hydroxylase deficiency (21OHD) born 2013–2022 and followed until age 3 years
- Participants
- 28 children
- Outcome
- Fludrocortisone dosing and associations of plasma renin with electrolytes, blood pressure and growth
Methodological detailssingle-centre, longitudinal
- Single-centre
- Longitudinal
Main finding
As reported in the abstract
Peak fludrocortisone dose at around 3 months
estimated mean 130 µg/day (95% CI 115-144)
Fludrocortisone dose plateau after 1 year
84 µg/day
95% CI 72–96
Observational data: associations, not effects.
Original publication
The role of renin, fludrocortisone, and hypertension in early childhood in patients with congenital adrenal hyperplasia. Eur J Endocrinol. Published 5 August 2026. doi:10.
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