Pharmacokinetics of inhaled prednisolone for adrenal crisis: an exploratory study
Authors' conclusion
The results of this study, particularly the short time to the target plasma concentration, indicate that prednisolone sodium succinate is rapidly absorbed via the lungs and that the pharmacokinetics of inhaled nebulized prednisolone sodium succinate are suitable for the outpatient treatment of adrenal crisis.
Study context
- Population
- Healthy participants aged 23–31 years, 50% femaleseach received both doses
- Participants
- 12 participants
- Comparison
- Inhaled prednisolone sodium succinate 56.1 mg vs 112.2 mg prednisolone equivalent
- Outcome
- Time to reach target plasma concentration of 200 nmol/L
Methodological detailsexploratory, healthy volunteers, nebulizer administration, two dose levels on separate occasions
- Exploratory
- Healthy volunteers
- Nebulizer administration
- Two dose levels on separate occasions
Main finding
As reported in the abstract
Time to plasma concentration 200 nmol/L (excluding nebulization time of ≈10 minutes)
Safety
Tolerability
- Pulmonary-administered prednisolone sodium succinate was well tolerated
Original publication
Pharmacokinetics of inhaled prednisolone for adrenal crisis: an exploratory study. Eur J Endocrinol. Published 4 August 2026. doi:10.
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