The Role of Prenatal Psychosocial Stress in the Associations of a Proinflammatory Diet in Pregnancy With Child Adiposity and Growth Trajectories
Authors' conclusion
The findings of this cohort study suggest that it may be useful to simultaneously evaluate prenatal diet and psychosocial stress in women as targets for interventions intended to prevent excess childhood adiposity.
Study context
- Population
- Singleton children of mothers enrolled April 1999–July 2002 in Massachusetts, followed at early childhood, midchildhood and early adolescence; mean (SD) maternal age 32.6 (4.6) years, 77% non-Hispanic White
- Participants
- 1,060 mother-child dyads
- Exposure
- Highest vs lowest quartile of prenatal Dietary Inflammatory Index (DII), modified by prenatal stress (Edinburgh Postnatal Depression Scale (EPDS), social vulnerability)
- Outcome
- Overall adiposity (BMI z, sum of subscapular and triceps skinfolds, FMI, body fat % by BIA and DXA) and central adiposity (waist circumference, subscapular:triceps skinfold ratio, DXA trunk FMI)
- Follow-up
- Early childhood, midchildhood, early adolescence
Methodological detailsProject Viva, mother-child dyads, Massachusetts, Data analysis October 31, 2020, to October 31, 2022
- Project Viva
- Mother-child dyads
- Massachusetts
- Data analysis October 31, 2020, to October 31, 2022
Main finding
As reported in the abstract
Adiposity trajectories, highest vs lowest DII quartile (adjusted) · over time
Β, BMI z change
0.03 SD units/y
95% CI 0.01–0.05
slower decrease in BMI z
Β, bioelectrical impedance analysis (BIA) total fat mass index (FMI) change
0.11 kg/m²/y
95% CI 0.03–0.19
faster adiposity gain
Observational data: associations, not effects.
Further findings
| Outcome | Change in β (Q4 vs Q1) (kg/m²) (95% CI) |
|---|---|
| Modification by EPDS (high vs low): DII Q4 vs Q1 association with BIA total FMIStronger association with high EPDS | 1.40 (0.21–2.59) |
β
High
0.55 (CI 0.04%–1.07%) % per year
Low
0.13 (CI −0.20–0.46%) % per year
- 95% CI
Modification by EPDS (high vs low): DII Q4 vs Q1 association with BIA total FMI
- EPDS scores did not modify the change over time
Original publication
The Role of Prenatal Psychosocial Stress in the Associations of a Proinflammatory Diet in Pregnancy With Child Adiposity and Growth Trajectories. JAMA Netw Open. Published 3 January 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →