The role of [18F]F-DOPA PET/CT in diagnostic and prognostic assessment of medullary thyroid cancer: a 15-year experience with 109 patients
Authors' conclusion
[18F]F-DOPA PET/CT had great value for diagnosis and prognostic assessment in patients with MTC. The DOPA PET/CT parameter SUVmean and MTV showed significant association with OS.
Study context
- Population
- Medullary thyroid cancer (MTC) patients who underwent [18F]F-DOPA PET/CT, June 2008 to November 2023; 50 women, 59 men; average age 55 ± 14 years
- Participants
- 109 patients
- Outcome
- Diagnostic and prognostic value of [18F]F-DOPA PET/CT in MTC
Methodological detailsretrospective review, June 2008 to November 2023
- Retrospective review
- June 2008 to November 2023
Performance
As reported in the abstract
Diagnostic performance of [18F]F-DOPA PET/CT
| Test or model | Patient-related sensitivity | Patient-related specificity | Patient-related accuracy | Lesion-related sensitivity | Lesion-related specificity | Lesion-related accuracy |
|---|---|---|---|---|---|---|
| [18F]F-DOPA PET/CT | 95% | 93% | 94% | 65% | 99% | 72% |
[18F]F-DOPA PET/CT
Patient-related sensitivity95%
Patient-related specificity93%
Patient-related accuracy94%
Lesion-related sensitivity65%
Lesion-related specificity99%
Lesion-related accuracy72%
Further findings
| Outcome | P value |
|---|---|
| OS by PET/CT resultNegative PET/CT vs Positive PET/CT · longer OS with negative PET/CT | P = 0.017 |
Optimal cutoffs for positive [18F]F-DOPA PET/CT
- Basal calcitonin (bCt) cutoff
- 64 pg/mL
- Stimulated calcitonin (sCt) cutoff
- 1808 pg/mL
- CEA cutoff
- 4 µg/L
Correlation of bCt, sCt and CEA with SUVmax, SUVmean and Metabolic Tumor Volume (MTV)
- Significant positive correlations
- P < 0.001
Prognostic factors
- Recurrent MTC: PET/CT results and MTV may be useful for prognosis
- Primary MTC: age and MTV independent prognostic factors
- All patients: SUVmean of left kidney, liver, aorta and pancreas might independently predict OS
Original publication
The role of [18F]F-DOPA PET/CT in diagnostic and prognostic assessment of medullary thyroid cancer: a 15-year experience with 109 patients. Eur Thyroid J. Published 13 July 2024. doi:10.
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