The renin‐angiotensin‐aldosterone system and salt sensitivity of blood pressure offer new insights in obesity phenotypes
Authors' conclusion
Compared to the MHOO group, the MUOO group was characterized by an increase in the following two CVD risk factors: higher RAAS activity and SSBP on controlled sodium diets. Therapeutic interventions targeting the effects of angiotensin II and/or aldosterone may offer cardiometabolic protection for individuals with the MUOO phenotype.
Study context
- Population
- Adults on controlled dietary sodium
- Participants
- 1,430 adults
- Exposure
- MUOO vs MHOO
- Outcome
- RAAS activity and SSBP, MUOO vs MHOO
- Follow-up
- Liberal sodium
Methodological detailscontrolled dietary sodium
- Controlled dietary sodium
Main finding
As reported in the abstract
liberal sodium
- Higher with MUOO; SD 0.48
- difference in plasma aldosterone concentration 1.11 ng/dL; P = 0.020
- SD 2.0
- difference in plasma angiotensin II 4.11 pg/mL; P = 0.040
- Higher with MUOO
- difference in % with plasma renin activity ≥ 1.0 ng/mL/h +3.6%; P = 0.017
- SD 1.9
- difference in salt sensitivity of blood pressure (SSBP) 6.0 mm Hg; P = 0.002
Observational data: associations, not effects.
Further findings
kg/m²
| Outcome | MHOO | MUOO | P value |
|---|---|---|---|
| BMIBetween MHOO and MUOO · BMI similar | 28.9 | 29.3 | P = 0.317 |
Metabolic health score (zero-to-six-point) vs renin-angiotensin-aldosterone system (RAAS) activity and SSBP
- Worse metabolic health score associated with higher RAAS activity and SSBP
- P < 0.001
Original publication
The renin‐angiotensin‐aldosterone system and salt sensitivity of blood pressure offer new insights in obesity phenotypes. Obesity (Silver Spring). Published 19 January 2025. doi:10.
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