Effect of a physical activity and healthy eating lifestyle intervention in pregnancy on fetal growth trajectories: The DALI randomised controlled trial
Authors' conclusion
A lifestyle intervention for pregnant women with obesity resulted in attenuated fetal growth, which only reached significance in male offspring. Future larger trials are needed to confirm these findings and elucidate underlying pathways.
Study context
- Population
- Pregnant women with BMI ≥29.0 kg/m² and without GDM at baseline
- Participants
- 384 women
- Comparison
- Physical activity (PA), healthy eating (HE) or PA + HE counselling vs usual care
- Primary endpoint
- Fetal growth trajectories modelled from EFW on repeated US scans and weight measured at birth
Primary result
As reported in the abstract
EFW (fetal growth trajectory) · 32, 36 and 40 weeks
PA + HE vs UCDifference, g (CI)
At 32 weeks
−54.1(−146.7 to 38.9)
At 36 weeks
−84.9(−194.0 to 24.7)
At 40 weeks
−99.8(−227.1 to 28.1)
Further findings
Estimated fetal weight (EFW), males · 40 weeks
- Effects appeared stronger in males; difference at 40 weeks
- −185.8 g (−362.5 g to −9.2 g)
EFW, females · 40 weeks
- Difference at 40 weeks in females
- −23.4 g (−190.4 g to 143.5 g)
Original publication
Effect of a physical activity and healthy eating lifestyle intervention in pregnancy on fetal growth trajectories: The DALI randomised controlled trial. Pediatr Obes. Published 19 January 2025. doi:10.
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