The prospective association between high-density lipoprotein (HDL) cholesterol and risk of incident fractures in the general population
Authors' conclusion
Higher HDL cholesterol levels are prospectively associated with 18% increased risk of new-onset fractures in men from the general population but not in women.
Study context
- Population
- General population cohort with available high-density lipoprotein cholesterol (HDL-C) data (mean age 69 years, 37% women), follow-up 2002 to December 31, 2020mean follow-up 13 years
- Participants
- 18,240 participants
- Exposure
- Higher vs lower HDL-C levels
- Incident fracturesn = 4,710
- Outcome
- Total incident fractures
- Follow-up
- Mean 13 years
Methodological detailspopulation-based, multivariate regression analysis
- Population-based
- Multivariate regression analysis
Main finding
As reported in the abstract
Total incident fractures per higher HDL-C, multivariate analysis
Hazard ratio (95% CI)P value
Higher HDL-C (general population)
1.12(1.03–1.22)
P = 0.006Higher HDL-C (men)
1.18(1.04–1.35)
P = 0.02Per higher HDL-C, as printed
Observational data: associations, not effects.
Secondary outcomes
HDL-C levels by fracture status
Incidence of fractures · mean follow-up 13 years
- Incident fractures in all subjects
- 26% (n = 4,710)
Incident hip and lower limb fractures
- No statistically significant relationship with HDL-C
- P > 0.05
Original publication
The prospective association between high-density lipoprotein (HDL) cholesterol and risk of incident fractures in the general population. Osteoporos Int. Published 31 October 2025. doi:10.
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