Impaired organic and mineral extracellular matrix composition in early-onset osteoporosis
Authors' conclusion
The matrix composition of bone showed greater damage of the organic matrix phase and reduced mineralization in EOOP patients than controls, which may explain the high risk of fracture in EOOP patients and may differentiate EOOP from other bone diseases.
Study context
- Population
- Adults with early-onset osteoporosis (mean [SD] age 34 [8] yr, LS BMD Z-score −2.05 [1.04]); vertebral fractures only, peripheral only, bothvertebral fractures only 7 · peripheral only 6 · both 3
- Participants
- 18 vs 19
- Comparison
- Early-onset osteoporosis (EOOP) vs age-matched healthy controls
- EOOPn = 18
- Controlsn = 19reference
- Outcome
- Bone microarchitecture (μCT) and matrix composition (Raman, FTIR)
Methodological detailshistorical controls, age-matched controls
- Historical controls
- Age-matched controls
Main finding
As reported in the abstract
- Hardness, indentation modulus and maximum load were all altered in EOOP (nanoindentation)
- PCA: greater contribution of organic and mineral matrix phase at trabecular and cortical EOOP bone than of microarchitecture
- EOOP vs Controls: P = 0.741
- EOOP vs Controls: P = 0.026
- EOOP vs Controls: P < 0.001
- EOOP vs Controls: P < 0.01
- EOOP vs Controls: all p < .0001
- EOOP vs Controls: all p < .005
Observational data: associations, not effects.
Original publication
Impaired organic and mineral extracellular matrix composition in early-onset osteoporosis. J Bone Miner Res. Published 30 October 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →