The Preoperative Paradoxical Growth Hormone (GH) Response to Oral Glucose Load Predicts a Low Risk of Recurrence in Acromegaly
Main finding · Recurrence of acromegalyResult — go to the resultHazard ratio 0.18 95% CI 0.05–0.63Authors' conclusion
Our study demonstrates that a paradoxical GH response to OGTT in the preoperative setting predicts a lower risk of disease recurrence after initial surgical cure. The pattern of GH responsiveness to OGTT is, therefore, useful to predict the long-term outcome of patients with acromegaly.
Study context
- Population
- Patients with acromegaly cured by surgery, OGTT at diagnosis before pituitary surgery, 2 tertiary care centers
- Participants
- 254 patients
- Exposure
- Paradoxical vs nonparadoxical GH response to preoperative OGTT
- GH-Parn = 87
- Outcome
- Recurrence of acromegaly after initial surgical cure
Methodological detailsobservational, 2 tertiary care centers
- Observational
- 2 tertiary care centers
Main finding
Recurrence of acromegaly
Hazard ratio
0.18
95% CI 0.05–0.63
P = 0.007
Events by group
GH-Parvs GH-NPar
HR 0.18 (95% CI 0.05–0.63); P = 0.007
As reported in the abstract
Observational data: associations, not effects.
Further findings
Basal GH level at diagnosis and risk of recurrence
- HR (multivariate), 95% CI 1.01-2.47; P = .04
- 1.58
- Only other variable associated with recurrence
Original publication
The Preoperative Paradoxical GH Response to Oral Glucose Load Predicts a Low Risk of Recurrence in Acromegaly. J Clin Endocrinol Metab. Published 15 June 2024. doi:10.
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