The Predictive Ability of C-Peptide in Distinguishing Type 1 Diabetes From Type 2 Diabetes: A Systematic Review and Meta-Analysis
Authors' conclusion
Plasma C-peptide levels are highly associated and predictive of the accurate classification and diagnosis of diabetes types. A plasma C-peptide cutoff of ≤0.20 mmol/L is indicative of T1D and of ≥0.30 mmol/L in the fasting or random state is indicative of T2D.
Study context
- Population
- Studies of plasma C-peptide in T1D and T2D; PubMed, MEDLINE, EMBASE and Scopus, citations 1942 to 2021; studies varied by race, age, time and proportion of individuals12 articles
- Comparison
- C-peptide levels in T1D vs T2D
- Outcome
- C-peptide levels
Methodological detailsPRISMA checklist, fixed- and random-effect models, 23,658 abstracts screened, 46 full texts reviewed
- PRISMA checklist
- Fixed- and random-effect models
- 23,658 abstracts screened, 46 full texts reviewed
Pooled result
As reported in the abstract
Predictive ability of C-peptide in discriminating T1D from T2D
Lower concentrations and fasting or random plasma C-peptide cutoff indicative of T1D
<0.20 nmol/L
Heterogeneity I2
98.8%
Original publication
The Predictive Ability of C-Peptide in Distinguishing Type 1 Diabetes From Type 2 Diabetes: A Systematic Review and Meta-Analysis. Endocr Pract. Published 11 January 2023. doi:10.
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