The liver fibrosis‐8 index is a predictor for all‐cause mortality in cardiovascular disease patients: A cohort study
Authors' conclusion
A positive and linear correlation was observed between the FIB-8 index and all-cause mortality among CVD adult participants in NHANES from 1999 to 2018. Our findings indicated that the FIB-8 index could serve as an excellent indicator for assessing all-cause mortality within the CVD population. The lower the FIB-8 index, the lower the all-cause mortality among CVD participants.
Study context
- Population
- American adults with cardiovascular diseases (CVD), National Health and Nutrition Examination Survey (NHANES) 1999–2018; mean age 61.68 ± 0.47 years, 59.19% men
- Participants
- 1,727 adults
- Exposure
- FIB-8 index and all-cause mortality
- Outcome
- All-cause mortality
Methodological detailsNHANES 1999–2018, weighted Cox regression, restricted cubic spline, sensitivity analyses, stratified analyses and interaction tests
- NHANES 1999–2018
- Weighted Cox regression
- Restricted cubic spline
- Sensitivity analyses
- Stratified analyses and interaction tests
Main finding
As reported in the abstract
All-cause mortality, per FIB-8 index (fully adjusted)
Hazard ratio (95% CI)
FIB-8 indexadjusted for relevant covariables
1.21(1.12–1.30)
Q3vs Q1fully adjusted model
1.88(1.23–2.87)
Q4vs Q1fully adjusted model
2.17(1.33–3.53)
Observational data: associations, not effects.
Further findings
Interaction tests
- No other covariables had significant interactions with the FIB-8 index
Original publication
The liver fibrosis‐8 index is a predictor for all‐cause mortality in cardiovascular disease patients: A cohort study. Diabetes Obes Metab. Published 4 October 2024. doi:10.
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