Associations of metabolic syndrome with cognitive function and dementia risk: Evidence from the UK Biobank cohort
Authors' conclusion
MetS was associated with poorer cognitive performance and might increase the risk of all-cause dementia as well as VaD, but the effect on Alzheimer's disease was not significant. Holistic control of the MetS may benefit the prevention and control of cognitive impairment and dementia.
Study context
- Population
- UK Biobank participants
- Participants
- 363,231 participants
- Exposure
- Metabolic syndrome (MetS) vs no MetS
- MetSn = 95,713
- Outcome
- Cognitive function, dementia and its subtypes
Methodological detailspopulation-based, UK Biobank
- Population-based
- UK Biobank
Main finding
As reported in the abstract
MetS vs No MetSHazard ratio (95% CI)
All-cause dementia, aged ≥60 years
1.115(1.047–1.187)
VaD, aged ≥60 years
1.393(1.233–1.575)
Observational data: associations, not effects.
Further findings
Brain structure
- MetS associated with alterations in overall brain, white matter and grey matter volume and white matter integrity
Original publication
Associations of metabolic syndrome with cognitive function and dementia risk: Evidence from the UK Biobank cohort. Diabetes Obes Metab. Published 3 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →