Association of metabolic score for visceral fat with all‐cause mortality, cardiovascular mortality, and cancer mortality: A prospective cohort study
Authors' conclusion
METS-VF was positively associated with all-cause mortality, cardiovascular mortality, and cancer mortality. These findings suggest that METS-VF could serve as a straightforward, reliable, and cost-effective marker for identifying individuals at high risk of mortality.
Study context
- Participants
- 11,120 participants
- Exposure
- Higher vs lower metabolic score for visceral fat (METS-VF)
- Outcome
- All-cause, cardiovascular and cancer mortality
- Follow-up
- Median 83 months
Methodological detailsweighted multivariable Cox regression, restricted cubic spline analyses, Mendelian randomization analysis
- Weighted multivariable Cox regression
- Restricted cubic spline analyses
- Mendelian randomization analysis
Main finding
As reported in the abstract
All-cause mortality, HR
1.13 (1.06, 1.20) (95% CI)
Cardiovascular mortality, HR
1.18 (1.06, 1.31) (95% CI)
Cancer mortality, HR
1.13 (1.03, 1.25) (95% CI)
Observational data: associations, not effects.
Further findings
Non-linearity (restricted cubic spline)
- No significant non-linear associations between METS-VF and all-cause, cardiovascular and cancer mortality
Highest METS-VF group vs reference group
- Hazard ratios (HRs) of all-cause, cardiovascular and cancer mortality higher in the highest METS-VF group vs reference
Prediction of mortality (ROC)
- METS-VF predicted mortality better than other obesity-related indicators
Mendelian randomization
- Significant causal relationships confirmed
Subgroup and sensitivity analyses
- Results robust
Original publication
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