The importance of targeting multiple risk markers in patients with type 2 diabetes: A post‐hoc study from the CANVAS programme
Authors' conclusion
In patients with type 2 diabetes, improvements in multiple risk markers were associated with a reduced risk of cardiovascular and kidney outcomes as compared with no risk marker improvement.
Study context
- Population
- Patients with T2D and high cardiovascular risk in the CANVAS programme, with data at baseline and week 26; improvements defined as reduction in HbA1c ≥1.0%, systolic BP ≥10 mmHg, body weight ≥3 kg, urinary albumin-creatinine ratio ≥30%, uric acid ≥0.5 mg/dl, and increase in haemoglobin ≥1.0 g/dl93.5% of participants
- Participants
- 9,487 patients
- Comparison
- Number of clinically relevant risk-marker improvements (zero to four or more) from baseline to week 26
- Primary endpoint
- Composite cardiovascular, HF/cardiovascular death and composite kidney outcomes
- Follow-up
- After week 26
Methodological detailsmultivariable-adjusted Cox proportional hazards regression
- Multivariable-adjusted Cox proportional hazards regression
Primary result
As reported in the abstract
Four or more vs ZeroAdjusted hazard ratio (95% CI)
Composite cardiovascular outcome
0.67(0.48–0.92)
HF/cardiovascular death
0.58(0.39–0.87)
Composite kidney outcome
0.49(0.25–0.96)
- Composite cardiovascular events
- 566
- HF/cardiovascular death events
- 370
- Composite kidney events
- 153
- Trend of decreased HRs with increasing number of risk marker improvements, composite cardiovascular
- P for trend = 0.008
- Trend of decreased HRs with increasing number of risk marker improvements, HF/cardiovascular death
- P for trend = 0.02
- Trend of decreased HRs with increasing number of risk marker improvements, composite kidney
- P for trend = 0.047
Original publication
The importance of targeting multiple risk markers in patients with type 2 diabetes: A post‐hoc study from the CANVAS programme. Diabetes Obes Metab. Published 7 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →