Cardiovascular outcomes trial data from EMPA‐REG OUTCOME , CAROLINA and CARMELINA : Assessment of a novel staging system for type 2 diabetes
Authors' conclusion
Applying the DSS across T2D clinical trial populations with different CV risk revealed a significantly increased risk of ACM and CV death with higher DSS stage. The DSS may merit assessment in other T2D populations and evaluation of the impact of additional outcomes, such as heart failure, could also be worthwhile.
Study context
- Population
- Patients with T2D from the CAROLINA, EMPA-REG OUTCOME and CARMELINA trials3 trials
- Comparison
- Higher vs lower diabetes staging system stage
- Primary endpoint
- All-cause mortality (ACM) and/or CV death by DSS stage
Methodological detailsEMPA-REG OUTCOME, CAROLINA, CARMELINA, Cox regression analyses
- EMPA-REG OUTCOME, CAROLINA, CARMELINA
- Cox regression analyses
Primary result
As reported in the abstract
ACM or CV death across DSS stages
- Risk of all-cause mortality (ACM) or cardiovascular (CV) death increased with increasing diabetes staging system (DSS) (Stage 1 to 5) in all trials
- P for trend <0.0001
Further findings
ACM and CV death by number of microvascular complications (A to D), CAROLINA
- Risk of ACM and CV death increased with increasing number of microvascular complications
- both P for trend <0.0001
ACM and CV death by number of microvascular complications (A to D), CARMELINA
- ACM: risk increased with increasing number of microvascular complications
- P for trend = 0.0020
- CV death: risk increased with increasing number of microvascular complications
- P for trend = 0.0005
ACM and CV death, Stage D vs none, EMPA-REG OUTCOME
- ACM: increased risk with all three microvascular complications (Stage D) vs none
- P = 0.0015
- CV death: increased risk with all three microvascular complications (Stage D) vs none
- P = 0.0010
Original publication
Cardiovascular outcomes trial data from EMPA‐REG OUTCOME , CAROLINA and CARMELINA : Assessment of a novel staging system for type 2 diabetes. Diabetes Obes Metab. Published 6 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →