Osteoporosis, bone & mineral

The Importance of Recent Prevalent Fracture Site for Imminent Risk of Fracture – A Retrospective, Nationwide Cohort Study of Older Swedish Men and Women

J Bone Miner ResPublished Retrospective cohort study

Authors' conclusion

All recent fractures, MOFs, and non-MOFs, as well as older fractures, increase the risk of subsequent fracture

Study context

Population
All Swedes aged ≥50 years between 2007 and 2010; followed until December 31, 2017
Participants
3,423,320 participants
Exposure
Recent major osteoporotic fracture (MOF), recent non-MOF and old fracture vs no previous fracture
  • Recent MOFn = 70,254
  • Recent non-MOFn = 75,526
  • Old fracturen = 293,051
  • Controlsn = 2,984,489reference
Outcome
Risk of any fracture
Methodological detailsnationwide, national registers
  • Nationwide
  • National registers

Main finding

As reported in the abstract

Any fracture
Adjusted for age and sex
Each group vs controlsHazard ratio (95% CI)
Recent MOF
2.11(2.08–2.14)
Recent non-MOF
2.24(2.21–2.27)
Old fracture
1.77(1.76–1.78)

Observational data: associations, not effects.

Further findings

Follow-up time

Original publication

The Importance of Recent Prevalent Fracture Site for Imminent Risk of Fracture – A Retrospective, Nationwide Cohort Study of Older Swedish Men and Women. J Bone Miner Res. Published 27 March 2023. doi:10.1002/jbmr.4806

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