The impact of hypoglycaemia on daily functioning among adults with diabetes: a prospective observational study using the Hypo-METRICS app
Authors' conclusion
This prospective, real-world study reveals impact on several domains of daily functioning following PRH but not following SDH alone. These data suggest that the observed negative impact is mainly driven by subjective awareness of hypoglycaemia (i.e. PRH), through either symptoms or sensor alerts/readings and/or the need to take action to prevent or treat episodes.
Study context
- Population
- Adults with T1D or insulin-treated T2D completing morning and evening Hypo-METRICS app check-ins
- Participants
- 594 adults
- Exposure
- Days and nights with vs without person-reported hypoglycaemia (PRH) and/or sensor-detected hypoglycaemia (SDH)
- T1Dn = 274
- T2Dn = 320
- Outcome
- Impact of hypoglycaemia (PRH and/or SDH) on daily functioning
- Follow-up
- 70 consecutive days
Methodological details70 consecutive days, blinded glucose sensor, multilevel regression models
- 70 consecutive days
- Blinded glucose sensor
- Multilevel regression models
Main finding
As reported in the abstract
Daily functioning after hypoglycaemia
- For both types of diabetes, SDH alone had no significant associations with changes in daily functioning scores
- Daytime and night-time PRH (with or without SDH) significantly associated with worsening energy levels, mood, cognitive functioning, negative affect and fear of hypoglycaemia later that day or while asleep
- Night-time PRH significantly associated with worsening sleep quality (T1D and T2D) and memory (T2D)
- Daytime PRH associated with worsening fear of hyperglycaemia while asleep (T1D), memory (T1D and T2D) and social functioning (T2D)
Observational data: associations, not effects.
Further findings
Check-in completion
- Morning check-ins submitted, mean ± SD
- 86.3±12.5%
- Evening check-ins submitted, mean ± SD
- 90.8±10.7%
Original publication
The impact of hypoglycaemia on daily functioning among adults with diabetes: a prospective observational study using the Hypo-METRICS app. Diabetologia. Published 30 July 2024. doi:10.
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