Diabetes complications

Recent Trends in Diabetic and Nondiabetic Neuropathies: A Retrospective Hospital-based Nationwide Cohort Study

Endocr PractPublished Retrospective cohort study

Authors' conclusion

Using a nationally representative database of hospital-admitted cases, we found that the incidence rates of DN and non-DN increased from 2010 to 2019. The main contributors were type 2 diabetes, inflammatory polyneuropathy, and uremic neuropathy.

Study context

Population
Hospitalizations with a primary or secondary discharge ICD-10 diagnosis code of neuropathy, Romania, 2010–2019
Participants
1,725,729 hospitalizations
Exposure
Diabetic neuropathy vs nondiabetic neuropathy
  • DNn = 769,324
  • non-DNn = 956,405
Outcome
Trends in the incidence of DN and non-DN
Follow-up
2010–2019
Methodological detailshospital-based, nationwide
  • Hospital-based
  • Nationwide

Main finding

As reported in the abstract

Incidence rate trend

DN

1.4%/year

mean

non-DN

4.3%/year

mean

Observational data: associations, not effects.

Further findings

Sex distribution

Women accounted for more DN cases
40 0 936- 52.1%
Men accounted for more non-DN cases
63 7 968- 61.0%

DN by diabetes type and neuropathy type

T2D responsible for overall increase in DN incidence; in T1D incidence decreased
Diabetic polyneuropathy predominant in both types; autonomic neuropathy incidence 10 to 20 times lower than polyneuropathy

Non-DN incidence increase by cause

Inflammatory polyneuropathies
+3.8%
Uremic neuropathy
+10.3%

Original publication

Recent Trends in Diabetic and Nondiabetic Neuropathies: A Retrospective Hospital-based Nationwide Cohort Study. Endocr Pract. Published 25 July 2024. doi:10.1016/j.eprac.2024.07.011

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