The impact of diabetes status on total and site-specific cancer risk in the elderly population: A nationwide cohort study
Authors' conclusion
Diabetes status is associated with increased risk of cancer in the elderly. There are age and sex differences in the risk of total and site-specific cancers, including liver, biliary, and pancreatic cancer. This study highlights the importance of cancer screening for elderly subjects with diabetes.
Study context
- Population
- Korean adults aged ≥65 years who underwent a general health screening program
- Participants
- 1,232,173 adults
- Exposure
- Diabetes status categories vs normal glucose tolerance
- Outcome
- Total and site-specific cancer risk
Methodological detailsCox proportional hazards models
- Cox proportional hazards models
Main finding
As reported in the abstract
- Risk of total cancer increased as diabetes status worsened
- Risks of liver, biliary and pancreatic cancer increased as diabetes status worsened
Observational data: associations, not effects.
Further findings
Liver, biliary and pancreatic cancer by age
- Risks significantly higher in subjects aged 65-74 years than in those aged ≥75 years
Overall cancer incidence by sex
- Relationship of diabetes status with overall cancer incidence significantly interacted with sex
Liver and lung cancer by sex among subjects with diabetes
- Risks significantly higher in men than in women regardless of diabetes duration
Original publication
The impact of diabetes status on total and site-specific cancer risk in the elderly population: A nationwide cohort study. Diabetes Res Clin Pract. Published 1 August 2023. doi:10.
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