Lipids & metabolic liver disease
The grade of obesity affects the noninvasive diagnosis of advanced fibrosis in individuals with MASLD
Authors' conclusion
The grade of obesity affects the detection of MASLD-related AF. A sequential use of LSM/A3+ could improve AF detection in patients with BMI ≥ 35.
Study context
- Population
- Patients with MASLD across a wide range of BMI, Lyon Hepatology Institute; median BMI 35.0 kg/m²consecutively included
- Participants
- 479 patients
- Comparison
- Liver stiffness measurement (LSM) vs Agile3+ for advanced fibrosis (AF), by BMI ≥35 vs <35
- Outcome
- Performance of noninvasive tests to detect AF (composite:
- Histological stage ≥ F3
- Cirrhosis by magnetic resonance elastography
- Concordant LSM ≥ 9.6 kPa and FibroTest ≥ F3)
Methodological detailsconsecutive inclusion, single-centre
- Consecutive inclusion
- Single-centre
Performance
As reported in the abstract
Specificity to rule in AF, BMI ≥ 35
| Test or model | Specificity |
|---|---|
| LSM | 77.9% |
| A3+ | 90.4% |
Specificity
LSM77.9%
A3+90.4%
Further findings
AF by BMI · lower with BMI ≥ 35
P < 0.001
Indeterminate status for AF by BMI · higher with BMI ≥ 35
P < 0.001
Prevalence of AF
- Prevalence of AF, whole cohort
- 28.6%
Original publication
The grade of obesity affects the noninvasive diagnosis of advanced fibrosis in individuals with MASLD. Obesity (Silver Spring). Published 3 May 2024. doi:10.
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