Lipids & metabolic liver disease
The association between triglyceride-glucose index and the likelihood of cardiovascular disease in the U.S. population of older adults aged ≥ 60 years: a population-based study
Authors' conclusion
A higher TyG index is linked to an increased likelihood of CVD in US adults aged ≥ 60 years. TyG index is anticipated to emerge as a more effective metric for identifying populations at early likelihood of CVD.
Study context
- Population
- US adults aged ≥60 years, NHANES 2003–2018
- Participants
- 6,502 adults
- Exposure
- Triglyceride-glucose (TyG) index quartiles
- Outcome
- Likelihood (odds) of CVD by TyG index
Methodological detailspopulation-based, weighted multivariable regression, restricted cubic splines, subgroup analysis
- Population-based
- Weighted multivariable regression
- Restricted cubic splines
- Subgroup analysis
Main finding
As reported in the abstract
CVD prevalence by TyG quartile
- Overall cardiovascular disease (CVD) prevalence
- 24.31%
- Mean TyG index
- 8.75 ± 0.01
- Threshold of TyG index for likelihood of CVD
- 8.73
Observational data: associations, not effects.
Further findings
Subgroup heterogeneity
- Significant interaction specifically for alcohol consumption; association dependent on drinking status
Original publication
The association between triglyceride-glucose index and the likelihood of cardiovascular disease in the U.S. population of older adults aged ≥ 60 years: a population-based study. Cardiovasc Diabetol. Published 3 May 2024. doi:10.
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