The effects of aging and frailty on inpatient glycemic control by continuous glucose monitoring in patients with type 2 diabetes
Authors' conclusion
Older adults with type 2 diabetes have better glycemic control prior to admission and during hospital stay compared to younger adults. Frailty is associated with longer presence of hypoglycemia in non-acute hospital settings.
Study context
- Population
- Hospitalised patients with T2D in non-acute settings wearing continuous glucose monitoring (CGM) (Libre or Dexcom G6)3 prospective studies
- Participants
- 103 vs 168
- Comparison
- Older adults ≥60 years vs younger adults <60 years; frailty (FI-LAB) and hypoglycemia
- Older adultsn = 103
- Younger adultsn = 168reference
- Outcome
- Time in range (TIR) 70-180 mg/dl during hospital stay
- Follow-up
- During hospital stay
Methodological detailsCGM-based, non-acute hospital settings
- CGM-based
- Non-acute hospital settings
Pooled result
As reported in the abstract
P = 0.02
Further pooled results
Admission HbA1c · lower with older adults
P < 0.001
Admission blood glucose · lower with older adults
P = 0.003
Mean daily BG · during hospital stay
P = 0.07
Frailty (FI-LAB) and hypoglycemia
- Higher FI-LAB score associated with higher % CGM <70 mg/dl
- 0.204
- Higher FI-LAB score associated with higher % CGM <54 mg/dl
- 0.217
- FI-LAB assessed in n = 85
Safety
- No difference in hypoglycemia occurrence between older and younger adults
Original publication
The effects of aging and frailty on inpatient glycemic control by continuous glucose monitoring in patients with type 2 diabetes. Diabetes Res Clin Pract. Published 5 March 2023. doi:10.
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