The effects of acute and chronic exercise on lipocalin-2 in middle-aged and older adults: a randomized control trial
Authors' conclusion
Acute-HIIE, but not 4 weeks of HIIT, transiently increased circulating LCN2 and improved insulin sensitivity in middle-aged and older adults. It remains unclear if LCN2 is modifiable by chronic exercise training longer than 4 weeks or in people with poor glycaemic control.
Study context
- Population
- Middle-aged and older adults (45–84 years, median BMI 26.21 kg/m²)
- Participants
- 33 participants
- Comparison
- 4 weeks of high-intensity interval training (HIIT) vs control, after an acute high-intensity interval exercise session (HIIE)
- Primary endpoint
- Effect of acute and chronic exercise on LCN2 levels
Primary result
As reported in the abstract
Serum LCN2 after acute HIIE · immediately, 1 and 3 h post-HIIE
- Main effect for time for serum LCN2, insulin, glucose and homeostatic model assessment for insulin resistance (HOMA-IR) after acute HIIE
- P < .001
- Serum LCN2 increased significantly immediately post-HIIE vs baseline
- P < .001
Further findings
VO2peak and physical function after 4 weeks of HIIT
- HIIT improved VO2peak
- No significant effect of HIIT on physical function
Original publication
The effects of acute and chronic exercise on lipocalin-2 in middle-aged and older adults: a randomized control trial. Eur J Endocrinol. Published 10 December 2025. doi:10.
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