The Effect of Gonadotropin-releasing Hormone Analog (GnRHa) Treatment on Body Mass Index in Central Precocious Puberty: A Systematic Review and Meta-Analysis
Pooled result · BMI-SDSResult — go to the resultWMD 0.14 95% CI 0.04–0.23Authors' conclusion
For patients with CPP, while treatment with GnRHa may increase the BMI in the short term after treatment, the BMI is likely to return to normal when the patients reach adult height.
Study context
- Population
- Patients with central precocious puberty (CPP); studies in PubMed, EMBASE and Web of Science published before August 202128 studies
- Comparison
- BMI-standard deviation score (BMI-SDS) at end of GnRHa treatment vs baseline
- Outcome
- BMI-SDS
- Follow-up
- End of GnRHa treatment
Pooled result
As reported in the abstract
Weighted mean difference (WMD)
0.14
95% CI 0.04–0.23
P = 0.004
End of GnRHa treatmentvs Baseline
WMD 0.14 (95% CI 0.04–0.23); P = 0.004
Further pooled results
| Outcome | WMD (95% CI) | P value | |
|---|---|---|---|
| BMI-SDS, girls with CPP · end of GnRHa treatment | 0.15 (0.05–0.25) | P = 0.005 | |
| BMI-SDS, normal-weight patients · end of GnRHa treatment | 0.34 (0.19–0.48) | P < 0.001 | |
| BMI-SDS after reaching adult height (returned to baseline)Adult heightvs Baseline | −0.03 (−0.39 to 0.32) | P = 0.815 | |
| −0.4−0.200.20.40.6Difference (linear scale) |
Original publication
The Effect of GnRHa Treatment on Body Mass Index in Central Precocious Puberty: A Systematic Review and Meta-Analysis. Horm Res Paediatr. Published 5 January 2024. doi:10.
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