The combined estimated glucose disposal rate and frailty index predicts cardiovascular events and mortality: A prospective cohort study from CHARLS
Authors' conclusion
The combined eGDRFI is a robust predictor of cardiovascular events and mortality in middle-aged and older adults, and may serve as a practical tool for risk stratification.
Study context
- Population
- Middle-aged and older adults from CHARLS
- Participants
- 6,684 participants
- Exposure
- eGDRFI quartiles Q4 vs Q1; per 1-unit increase
- Outcome
- Incident CVD, stroke, heart disease and all-cause mortality
Main finding
As reported in the abstract
Q4 vs Q1Hazard ratio (95% CI)P value
CVD; adjusted
1.833(1.494–2.249)
P < 0.001Mortality; adjusted
1.511(1.212–1.884)
P < 0.001- Cardiovascular diseases (CVD), HR per 1-unit increase in eGDRFI (adjusted), 95% CI 1.061-1.136, P < 0.001
- 1.098
- All-cause mortality, HR per 1-unit increase in eGDRFI (adjusted), 95% CI 1.048-1.113, P < 0.001
- 1.080
Observational data: associations, not effects.
Further findings
Discrimination (ROC) for incident CVD
- eGDRFI AUC
- 0.600
- Estimated glucose disposal rate (eGDR) AUC
- 0.590
- Frailty index (FI) AUC
- 0.563
Discrimination (ROC) for all-cause mortality
- eGDRFI AUC
- 0.606
- eGDR AUC
- 0.547
- FI AUC
- 0.601
Original publication
The combined estimated glucose disposal rate and frailty index predicts cardiovascular events and mortality: A prospective cohort study from CHARLS. Diabetes Res Clin Pract. Published 9 April 2026. doi:10.
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