Plasma biomarkers of neurodegeneration and their associations with type 1 diabetes characteristics and glycemia
Authors' conclusion
Higher NfL was linked with multiple measures of hyperglycemia and other diabetes-related complications, consistent with neuronal injury rather than suggesting an ADRD-specific process. Longitudinal studies are needed to clarify the mechanisms between NfL and glycemia in T1D.
Study context
- Population
- Adults with T1D from the GluCog Study with available plasma samples
- Participants
- 114 adults
- Outcome
- Associations of plasma ADRD biomarkers (Aβ42/Aβ40 ratio, GFAP, NfL, pTau181, pTau217) with diabetes characteristics and CGM metrics
Methodological detailsregression models adjusted for demographics and kidney disease, false discovery rate correction
- Regression models adjusted for demographics and kidney disease
- False discovery rate correction
Main finding
As reported in the abstract
- Lower Aβ42/Aβ40 ratios associated with older age at T1D diagnosis
- Higher NfL associated with higher mean glucose, lower TIR, more time with glucose >180 and >250 mg/dL, higher HbA1c, neuropathy and DKA
- Associations remained significant after additional adjustment for kidney disease; residual confounding by renal function cannot be excluded
Observational data: associations, not effects.
Original publication
Plasma biomarkers of neurodegeneration and their associations with type 1 diabetes characteristics and glycemia. Diabetes Res Clin Pract. Published 8 April 2026. doi:10.
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