The Burden of Obesity in Type 1 Diabetic Subjects: A Sex-specific Analysis From the AMD Annals Initiative
Authors' conclusion
Obesity is a frequent finding in T1D adult subjects, and it is associated with a higher burden of cardiovascular disease risk factors, micro- and macrovascular complications, and a lower quality of care, with no major sex differences. T1D women are at higher risk of severe obesity.
Study context
- Population
- Adults with T1D attending 282 Italian diabetes clinics during 2019, AMD Annals Initiative; 45.3% women
- Participants
- 37,436 adults282 clinics
- Exposure
- Women vs men
- Outcome
- Prevalence of obesity (BMI ≥30 kg/m²) and severe obesity (BMI ≥ 35 kg/m²) by sex
Methodological detailsmulticentre, sex-specific analysis
- Multicentre
- Sex-specific analysis
Main finding
As reported in the abstract
Obesity prevalence
- Severe obesity (body mass index (BMI) >35 kg/m²) more prevalent among women: higher risk vs men at multivariate analysis
- 45%
Observational data: associations, not effects.
Further findings
CVD risk factors, quality of care and complications by obesity
- CVD risk factors (lipid profile, glucose and blood pressure control) and overall quality of care worse in obese subjects, with no major sex-related differences
- Micro- and macrovascular complications more frequent among obese than nonobese T1D men and women
Original publication
The Burden of Obesity in Type 1 Diabetic Subjects: A Sex-specific Analysis From the AMD Annals Initiative. J Clin Endocrinol Metab. Published 29 May 2023. doi:10. 1210/ clinem/ dgad302
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