The Brain-derived Neurotrophic Factor (BDNF) Protein is Associated With Glucose Homeostasis and Food Intake in Carriers of Common BDNF Gene Variants
Authors' conclusion
Peripheral BDNF may be associated with VAT content and insulin concentrations in GG genotype carriers and may vary with particular food intake, which warrants further investigation.
Study context
- Population
- Participants genotyped for common BDNF rs10,835,211 variants; fasting and OGTT glucose and insulin, body composition, 3-day food diary and food frequency questionnaire
- Participants
- 439 participants
- Exposure
- BDNF rs10835211 genotypes
- Outcome
- BDNF concentration by rs10835211 genotype
Main finding
As reported in the abstract
- Positive correlation between age and BDNF, whole population
- P = .012
- Positive correlation between age and BDNF, GG carriers
- P = .023
- BDNF correlated with fasting insulin, GG carriers
- P = .015
- BDNF correlated with HOMA-IR, GG carriers
- P = .031
- BDNF correlated with HOMA-B, GG carriers
- P = .010
- BDNF correlated with VAT/SAT ratio, GG carriers
- P = .026
- GG genotype negatively correlated with nut and seed consumption
- P = .047
- GG genotype negatively correlated with lean pork consumption
- P = .015
- Frequency of chicken intake correlated with BDNF, general population
- P = .028
- Frequency of pasta intake correlated with BDNF, general population
- P = .033
- Frequency of sweet food intake correlated with BDNF, general population
- P = .040
- Positive correlation of rice consumption with BDNF, AA carriers
- P = .048
- Positive correlation of sweet food consumption with BDNF, AA carriers
- P = .028
Observational data: associations, not effects.
Original publication
The BDNF Protein is Associated With Glucose Homeostasis and Food Intake in Carriers of Common BDNF Gene Variants. J Clin Endocrinol Metab. Published 13 March 2024. doi:10.
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