Cardiovascular Risk in Women With Nonclassical Congenital Adrenal Hyperplasia
Authors' conclusion
Adult females with NCAH did not show increased CVR using methodologies for detection of precocious atherosclerosis. Although patients receiving dexamethasone therapy had increased IL-6 and IL-8 levels, these data were not associated with radiological markers of atherosclerosis. Our cohort was composed of young adults and should be reevaluated in a long-term follow-up.
Study context
- Population
- Females with nonclassical CAH (33.4 ± 10 years), tertiary center47 NCAH + 30 matched controls
- Participants
- 28 / 19 / 30
- Exposure
- Dexamethasone vs oral contraceptive pills vs matched controls in NCAH
- G1n = 28
- G2n = 19
- G3n = 30reference
- Outcome
- Cardiovascular risk (CVR) by markers of atherosclerosis: serum lipids, HOMA-IR, inflammatory cytokines, PWV, FMD, CIMT, VAT by abdominal CT
Methodological detailssingle tertiary center, matched controls
- Single tertiary center
- Matched controls
Main finding
As reported in the abstract
Markers of atherosclerosis and CVR
- No significant differences in BMI, Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), HDL-C or TG among groups
- P > .05
- No significant differences in VAT, pulse wave velocity (PWV), flow-mediated dilatation (FMD) or carotid intima media thickness (CIMT) among groups
- P > .05
Observational data: associations, not effects.
Original publication
Cardiovascular Risk in Women With Nonclassical Congenital Adrenal Hyperplasia. J Clin Endocrinol Metab. Published 11 March 2024. doi:10.
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