Gestational diabetes & diabetes in pregnancy

The association between offspring birthweight and future risk of maternal diabetes: A population‐based study

Diabet MedPublished Retrospective cohort study

Main finding · Incident maternal diabetesResult — go to the resultAdjusted hazard ratio 2.30 95% CI 2.16–2.46

Authors' conclusion

A higher offspring birthweight signals an increased risk of maternal diabetes, offering another potentially useful way to identify women especially predisposed to diabetes.

Study context

Population
Women aged 16–50 years without pre-pregnancy diabetes with a live birth between 2006 and 2014, Ontario, Canada
Participants
893,777 women
Exposure
Offspring birthweight percentile categories
Outcome
Incident maternal diabetes after pregnancy
Follow-up
Median (IQR) 4.4 (1.5-7.4) years
Methodological detailspopulation-based, linked health databases
  • Population-based
  • Linked health databases

Main finding

Incident maternal diabetes

Adjusted hazard ratio

2.30

95% CI 2.16–2.46

97th–100th percentilevs 50th–74.9th percentile
aHR 2.30 (95% CI 2.16–2.46)

As reported in the abstract

Observational data: associations, not effects.

Further findings

OutcomeaHR
Incident maternal diabetes, women with GDM2.01 (95% CI 1.83–2.21)
Incident maternal diabetes, women without GDM2.59 (CI 2.36–2.84)

Diagnosed with diabetes (overall) · median 4.4 years

Women diagnosed with diabetes
14,329 (1.6%)

Original publication

The association between offspring birthweight and future risk of maternal diabetes: A population‐based study. Diabet Med. Published 5 November 2022. doi:10.1111/dme.14991

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