The 1-hour plasma glucose as a specific marker for early-phase insulin secretory defects in young adults with obesity
An erratum to this article was published (Diabetes Res Clin Pract, Oct 2026 ↗)
Authors' conclusion
1-h PG is a specific physiological marker of early-phase insulin secretion defects, supporting its role in early phenotyping and risk stratification in young adults with obesity.
Study context
- Population
- Chinese young adults (18–40 years) with obesity (BMI ≥ 28 kg/m²) and without diabetesFrequently sampled intravenous glucose tolerance test (FSIVGTT) subcohort n = 495
- Participants
- 2,178 adults
- Exposure
- 1-h PG vs other glycemic markers
- Outcome
- Identification of impairments in insulin secretion, sensitivity and β-cell compensation
Methodological detailsFSIVGTT subcohort
- FSIVGTT subcohort
Main finding
As reported in the abstract
Early-phase insulin secretion defects
| Group | Correlation with IGI30 (ρ) | AUC |
|---|---|---|
| 1-h PG | - 0.413 | 0.702 |
1-h PG
Correlation with IGI30 (ρ)- 0.413
AUC0.702
Observational data: associations, not effects.
Further findings
Insulin sensitivity
- 1-h PG correlated more strongly with the Matsuda index, whereas 2-h PG was more strongly associated with FSIVGTT-derived sensitivity (SI)
Elevated 1-h PG
- Elevated 1-h PG identified individuals with impairments across all traits
- ≥8.6 mmol/L
Original publication
The 1-hour plasma glucose as a specific marker for early-phase insulin secretory defects in young adults with obesity. Diabetes Res Clin Pract. Published 24 May 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →