Testicular volume in 268 children and adolescents followed-up for childhood obesity—a retrospective cross-sectional study
Authors' conclusion
Closer control of the body weight and the associated metabolic alterations in childhood and adolescence may maintain testicular function later in life.
Study context
- Population
- Children and adolescents followed-up for weight control (childhood obesity); pre-pubertal (<9 years), peri-pubertal (9–14 years), post-pubertal (14–16 years)
- Participants
- 268 children
- Exposure
- Normal weight vs overweight/obesity; normal insulin vs hyperinsulinemia; insulin resistance vs none
- Outcome
- Testicular volume (TV) by obesity, hyperinsulinemia and insulin resistance
Main finding
As reported in the abstract
Testicular volume
- Peri-pubertal boys with normal weight had significantly higher testicular volume (TV) than those with overweight or obesity
- No difference in other age ranges by body mass index (BMI)
- Pre- and post-pubertal: normal insulin levels had significantly higher TV than hyperinsulinemia
- Peri-pubertal: hyperinsulinemia had significantly higher TV than normal insulin levels
- Insulin resistance: lower TV in post-pubertal, higher TV in peri-pubertal vs no insulin resistance; no difference in pre-puberty
Observational data: associations, not effects.
Original publication
Testicular volume in 268 children and adolescents followed-up for childhood obesity—a retrospective cross-sectional study. Eur J Endocrinol. Published 18 April 2023. doi:10.
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