Weight loss relapse associated with exposure to perfluorinated alkylate substances
Authors' conclusion
Elevated plasma concentrations of PFOA and PFHxS were associated with increased weight gain that exceeded those related to the diets. Obesogenic PFASs may cause weight gain and thus contribute to the obesity pandemic.
Study context
- Population
- Adults with obesity who first lost at least 8% of body weight and then completed at least 26 weeks on a specific dietcomplete data
- Participants
- 381 adults
- Comparison
- Plasma perfluorinated alkylate substance (PFAS) exposure and weight change
- Primary endpoint
- Weight increase
- Follow-up
- 26 weeks
Primary result
As reported in the abstract
Weight change per doubling in plasma PFAS
Weight increase per doubling of plasma perfluorooctanoic acid (PFOA), kg
1.50 (0.88-2.11) (95% CI)
Weight increase per doubling of plasma PFHxS, kg
0.91 (0.54-1.27) (95% CI)
Further findings
Baseline plasma concentrations (average)
ng/mL
- PFOA
- 2.9
- PFHxS
- 1.0
PFAS-associated vs diet-associated weight change
- Weight changes associated with elevated PFAS exposures were similar to or larger than average changes ascribed to the diet groups
Original publication
Weight loss relapse associated with exposure to perfluorinated alkylate substances. Obesity (Silver Spring). Published 17 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →