Ten‐year progression of obesity‐related complications in a population with overweight and obesity in the UK : A retrospective open cohort study
Authors' conclusion
Higher BMI was associated with higher baseline ORC prevalence and a greater increase in ORC prevalence over time, and with higher healthcare costs in those with multimorbidity. To reduce the burden of overweight and obesity on patients and healthcare systems, the presence, number and type of ORCs should be considered in developing effective, targeted prevention and management care pathways.
Study context
- Population
- Adults with overweight or obesity in Discover, a UK database of linked primary and secondary electronic health records, 1 January 2004 to 31 December 2019
- Participants
- 1,410,146 adults
- Exposure
- Body mass index (BMI) categories: obesity classes I–III vs overweight
- Overweightn = 1,008,101reference
- Obesity class In = 278,782
- Obesity class IIn = 80,621
- Obesity class IIIn = 42,642
- Outcome
- Prevalence of individual obesity-related complications (ORCs) and multimorbidity (≥ 1, ≥ 2 and ≥ 3 ORCs), and multimorbidity-associated healthcare costs
- Follow-up
- Over 10 years
Methodological detailsopen cohort, serial cross sections, linked primary and secondary electronic health records
- Open cohort
- Serial cross sections
- Linked primary and secondary electronic health records
Main finding
As reported in the abstract
ORC prevalence
- ORC prevalence was higher in successive BMI groups
- Increases in ORC prevalence over time generally greater for obesity vs overweight
Observational data: associations, not effects.
Further findings
Annual per-person healthcare costs in those with ORC multimorbidity
- Higher BMI and more obesity-related complications (ORCs) associated with higher annual per-person healthcare costs
- Costs increased over time with obesity and ≥1 ORC, and with obesity and ≥2 ORCs
Original publication
Ten‐year progression of obesity‐related complications in a population with overweight and obesity in the UK : A retrospective open cohort study. Diabetes Obes Metab. Published 19 August 2024. doi:10.
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