Novel Glucose Metric “Latest Spike Time” Correlated with Weight Loss at Six Months in People with Obesity Using the Signos System
Authors' conclusion
In a large population of obese people without diabetes, continuous glucose data, specifically a novel metric "LST," was highly correlated with percentage of total body weight loss at 6 months.
Study context
- Population
- People with obesity without diabetes enrolled in the Signos System (continuous glucose monitoring (CGM) plus digital health app), November 2021 to August 2023
- Participants
- 926 people
- Exposure
- Earlier vs later latest spike time
- Outcome
- Correlation of average timing of the latest glucose excursion (LST) with weight loss
- Follow-up
- 6 months
Methodological detailsretrospective analysis of prospectively obtained data
- Retrospective analysis of prospectively obtained data
Main finding
As reported in the abstract
Weight loss by LST
- Strong correlation between earlier spike time and increased weight loss
- Top quintile (Latest spike time (LST) before 5:41 PM) lost over three times as much weight as bottom quintile (LST after 8:40 PM)
Observational data: associations, not effects.
Further findings
Early predictability of separation · 1 month
- Separation predictable within 1 month of data
Original publication
Novel Glucose Metric “Latest Spike Time” Correlated with Weight Loss at Six Months in People with Obesity Using the Signos System. Diabetes Technol Ther. Published 19 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →