Temporal trends in socioeconomic inequalities and risk of infection after hip fracture surgery: a nationwide cohort study, 2010–2021

Osteoporos IntPublished Nationwide cohort study

Authors' conclusion

Our results indicate growing inequality in health among patients with hip fracture, whereby lower education, lack of social support, and reliance on residential care represent increasing disadvantages for infection risk.

Study context

Population
Patients with hip fracture undergoing surgery, Danish population-based registries, 2010–2021
Participants
74,068 patients
Exposure
Socioeconomic position markers across four calendar periods, 2010–2021
Outcome
Any hospital-treated or community-treated infection after surgery; inequality measured by adjusted SII (hazard difference/100 person years) and adjusted RII (relative hazard)
Follow-up
30 days after surgery
Methodological detailspopulation-based registries, additive hazard regression, Cox proportional hazard regression
  • Population-based registries
  • Additive hazard regression
  • Cox proportional hazard regression

Main finding

As reported in the abstract

Inequality in hospital-treated infections, 2010 vs 2021 · 30 days
Education, 2010: Slope index of inequality (SII)
14 [- 20; 49]
Education, 2010: Relative index of inequality (RII)
1.1 [0.9; 1.3]
Education, 2021: SII
36 [0; 71]
Education, 2021: RII
1.2 [1; 1.3]
Marital status, 2010: SII
29 [- 9; 66]
Marital status, 2010: RII
1.2 [1; 1.4]
Marital status, 2021: SII
84 [45; 123]
Marital status, 2021: RII
1.4 [1.2; 1.7]
Living arrangements, 2010: SII
- 32 [- 78; 14]
Living arrangements, 2010: RII
0.9 [0.7; 1.1]
Living arrangements, 2021: SII
106 [59; 153]
Living arrangements, 2021: RII
1.5 [1.3; 1.8]

Observational data: associations, not effects.

Further findings

Incidence of hospital-treated infections · 30 days

Total patients with hospital-treated infection
12,654
Range by calendar period and socioeconomic position
14 and 21%

Incidence of community-treated infections · 30 days

Total patients with community-treated infection
20,523
Range by calendar period and socioeconomic position
21 and 38%

Inequality in community-treated infections · 30 days

Similar trends observed as for hospital-treated infections

Original publication

Temporal trends in socioeconomic inequalities and risk of infection after hip fracture surgery: a nationwide cohort study, 2010–2021. Osteoporos Int. Published 23 June 2025. doi:10.1007/s00198-025-07576-0

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