Temporal trends and clinical factors associated with hypoglycemia-related hospitalization of patients with type 2 diabetes: a large-scale claims database study in Japan
Authors' conclusion
Hypoglycemia-related hospitalization declined in Japan during 2009-2022, with the residual burden remaining concentrated among older adults.
Study context
- Population
- Patients receiving glucose-lowering medications for T2D, Japanese hospital-based claims data 2009–2022
- Participants
- 1,391,948 patients
- Outcome
- Hospitalization for hypoglycemia (codes for diagnosis, same-day hospitalization and IV 50% glucose)
Methodological detailshospital-based claims database, modified Poisson regression
- Hospital-based claims database
- Modified Poisson regression
Main finding
As reported in the abstract
Hospitalization for hypoglycemia · 2009-2022
Patients hospitalized for hypoglycemia, overall
7,157
Annual frequency in 2009
0.41%
Annual frequency in 2022
0.21%
Observational data: associations, not effects.
Secondary outcomes
Factors associated with all hypoglycemia-related outcomes (hospitalization, nocturnal hospitalization, emergency transport)
- Older age and lower BMI were associated with all hypoglycemia-related outcomes
- Insulin, pioglitazone, GLP-1 RA, alpha-glucosidase inhibitors and SU were associated with all hypoglycemia-related outcomes
Kidney function (sensitivity analysis)
- Impaired kidney function was associated with an increased risk
- Sensitivity analysis
Original publication
Temporal trends and clinical factors associated with hypoglycemia-related hospitalization of patients with type 2 diabetes: a large-scale claims database study in Japan. Diabetes Res Clin Pract. Published 27 August 2026. doi:10.
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