γδ T cell exhaustion is associated with obesity in individuals with type 2 diabetes
Authors' conclusion
Together, these findings indicate that obesity may exacerbate the exhaustion of circulating γδ T cells in T2D, highlighting a potential link between metabolic dysregulation and innate immune dysfunction.
Study context
- Population
- Individuals with clinically diagnosed T2D and age- and sex-matched healthy donors
- Participants
- 54 vs 30
- Exposure
- T2D vs healthy donors
- T2Dn = 54
- Healthy donorsn = 30reference
- Outcome
- Circulating γδ T cells and exhaustion markers
Methodological detailsage- and sex-matched healthy controls, flow cytometry
- Age- and sex-matched healthy controls
- Flow cytometry
Main finding
As reported in the abstract
- Significant reduction in proportion of circulating innate-like γδ T cells in T2D vs healthy controls
- Exhaustion markers PD-1, Tim-3 and TIGIT markedly elevated on γδ T cells in T2D
- Obesity positively correlated with co-expression of PD-1 and TIGIT, and of PD-1 and Tim-3, on γδ T cells
Observational data: associations, not effects.
Original publication
γδ T cell exhaustion is associated with obesity in individuals with type 2 diabetes. Int J Obes (Lond). Published 3 April 2026. doi:10.
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