Systolic blood pressure status modifies the associations between the triglyceride-glucose index and incident cardiovascular disease: a national cohort study in China
Authors' conclusion
The associations between the TyG index and CVD were modified by BP status, with greater HRs for CVD observed among those who had SBP < 130mmHg. SBP can partially mediate the association between the TyG index with CVD, highlighting the importance of early screening for the TyG index to identify at risk of hypertension and CVD.
Study context
- Population
- Chinese middle-aged and elderly adults without prevalent cardiovascular disease (CVD) (mean age 58.3 (± 8.7) years; 46.0% men), grouped by systolic blood pressure (SBP) (< 120mmHg, 120 ∼ 129mmHg, ≥ 130mmHg)
- Participants
- 6,558 participants
- Exposure
- Higher vs lower triglyceride-glucose (TyG) index, by SBP status
- Outcome
- Incident CVD (heart disease and stroke)
Methodological detailsnational cohort, China Health and Retirement Longitudinal Study
- National cohort
- China Health and Retirement Longitudinal Study
Main finding
As reported in the abstract
Incident CVD · 58,333 person-years of follow-up
Hazard ratio (95% CI)
Per 1-SD higher TyG index19% higher risk
1.19(1.12–1.27)
Highest TyG quartilevs Lowest TyG quartile54% higher risk
1.54(1.29–1.84)
- CVD cases
- 1599
Observational data: associations, not effects.
Secondary outcomes
Consistency by other blood pressure (BP) statuses
- Results generally consistent across pulse pressure statuses rather than diastolic BP statuses
Original publication
Systolic blood pressure status modifies the associations between the triglyceride-glucose index and incident cardiovascular disease: a national cohort study in China. Cardiovasc Diabetol. Published 24 April 2024. doi:10.
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