Systematic Review—Type B Insulin Resistance With Isolated Hypoglycemia and Suppressed Insulin
Authors' conclusion
Isolated hypoglycemia with low insulin forms a rare subgroup of type B insulin resistance. These patients lack the common characteristics of hyperinsulinemic hypoglycemia and hyperglycemia/insulin resistance. Furthermore, while coexisting autoimmune disease is commonly observed, there is potentially an association with aggressive lymphoma, the onset of which may be delayed.
Study context
- Population
- Cases of type B insulin resistance with isolated hypoglycemia and suppressed insulin; excluded: hyperglycemia, elevated insulin, AIRAbs not confirmed
- Participants
- 11 case reports
- Outcome
- Clinical characteristics and outcome of the isolated hypoglycemia with low insulin subgroup
Methodological detailsJoanna Briggs Institute critical appraisal checklist for case reports, PubMed, Medline and Embase searched up to February 2023, plus manual citation search; 5342 articles after duplicate removal
- Joanna Briggs Institute critical appraisal checklist for case reports
- PubMed, Medline and Embase searched up to February 2023, plus manual citation search; 5342 articles after duplicate removal
Pooled result
As reported in the abstract
Clinical characteristics and outcome
Developed lymphoma
3 of 11 cases
Original publication
Systematic Review—Type B Insulin Resistance With Isolated Hypoglycemia and Suppressed Insulin. J Clin Endocrinol Metab. Published 8 August 2023. doi:10.
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