Synergistic interaction and cumulative effect between frailty and triglyceride-glucose index exacerbate cardiovascular disease burden in middle-aged and older adults
Authors' conclusion
Frailty and high TyG synergistically elevate the risk of incident CVD, with cumulative effects intensifying this association.
Study context
- Population
- Middle-aged and older adults, China Health and Retirement Longitudinal Study (CHARLS); mean age 57.51 ± 8.40 years, 48.39 % male3,194 in cumulative analysis
- Participants
- 5,997 participants
- Exposure
- Frailty and higher TyG vs neither
- Outcome
- Incident CVD
- Follow-up
- Nine years
Main finding
As reported in the abstract
Both frailty status and higher TyG: highest risk of incident cardiovascular disease (CVD), aHR
2.53 (2.06-3.12) (95 % CI)
Observational data: associations, not effects.
Further findings
Mediation by frailty of TyG–CVD association
- Proportion mediated by frailty status
- 14.22 %
Cumulative effects: incident CVD
- Upper cumulative frailty index and higher cumulative TyG: highest risk of incident CVD, aHR
- 3.13 (2.30-4.25) (95 % CI)
- 3,194 without CVD events 2011–2015
Original publication
Synergistic interaction and cumulative effect between frailty and triglyceride-glucose index exacerbate cardiovascular disease burden in middle-aged and older adults. Diabetes Res Clin Pract. Published 27 June 2025. doi:10.
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