Synergies between diabetes and hyperhomocysteinaemia: New insights to predict and prevent adverse cardiovascular effects
Main finding · Composite endpointResult — go to the resultHazard ratio 1.97 95% CI 1.47–2.65Authors' conclusion
The findings highlight the synergistic impact of diabetes and HHcy on CVD. Joint assessments of diabetes and Hcy levels should be emphasized for risk stratification and primary prevention of CVD.
Study context
- Population
- Adults in northern China, Asymptomatic Polyvascular Abnomalities Community study, 2010–2019; mean age 55.1 years, 60% male
- Participants
- 5,278 adults
- Exposure
- Diabetes/HHcy vs non-diabetes/non-HHcy
- Outcome
- Composite of:
- First-ever stroke
- MI
- All-cause mortality
- Follow-up
- 9.1 years
Methodological detailscommunity-based
- Community-based
Main finding
Composite endpoint
Hazard ratio
1.97
95% CI 1.47–2.65
Diabetes/HHcyvs Non-diabetes/non-HHcy
HR 1.97 (95% CI 1.47–2.65)
As reported in the abstract
- Events (202 stroke, 52 myocardial infraction (MI), 406 all-cause deaths)
- 618
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| StrokeDiabetes/HHcyvs Non-diabetes/non-HHcyInteraction HHcy × diabetes | 1.85 (1.12–3.04) | P for interaction = 0.002 | |
| MIDiabetes/HHcyvs Non-diabetes/non-HHcyInteraction HHcy × diabetes | 1.33 (0.42–4.23) | P for interaction = 0.027 | |
| MACEDiabetes/HHcyvs Non-diabetes/non-HHcyInteraction HHcy × diabetes | 1.78 (1.13–2.80) | P for interaction = 0.044 | |
| All-cause deathDiabetes/HHcyvs Non-diabetes/non-HHcy | 2.24 (1.56–3.23) | ||
| 0.20.5125Hazard ratio (log scale) |
- Stroke — Diabetes/HHcy–stroke association modified by age (<60 vs ≥60 years); P for interaction
- .016
Original publication
Synergies between diabetes and hyperhomocysteinaemia: New insights to predict and prevent adverse cardiovascular effects. Diabetes Obes Metab. Published 21 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →